Published on 22 September 2026, the collaborative study introduces a microfluidic integrated mRNA amplification circuit (MIMAC). Oscillatory shear reorganizes preformed lipid nanoparticles (LNPs) to study RNA organization and release order.
Li-in’s participation in the collaboration
Co-corresponding author Lei Zhang lists affiliations with the University of Waterloo and “Li-in Biotech Co., Ltd, Huzhou, China”. The paper acknowledges Li-in’s technical team for sample-characterization and animal-experiment support.
Chip & flow engineering
How can microchannels influence particle assembly? The NBE study uses oscillatory shear to reorganize preformed particles, connecting flow design with delivery-system research.
Spatial organization and sequential release
MIMAC positions added metabolism-enhancing RNA in an internal peripheral region while redistributing the original target RNA toward the core. The study explores peripheral RNA release and metabolic priming before subsequent target-RNA expression.
Research evidence and stage
The paper combines DLS particle-size analysis, cryo-TEM and super-resolution confocal microscopy with in vitro experiments and mouse models. The findings offer a design direction for further RNA-delivery research.